The emphasis is put on applications of micro and nanosystems to various different disciplines such as tissue. This thesis is based on the following original papers, which are referred to in the text with roman numerals i vi. The objective of this work was to prepare and evaluate sa me systems. Selfnanoemulsifying drug delivery systems snedds for. Volume 5 number 4 aug 2015 114 available online at. Micelles, microemulsions, liquid crystals, and the.
Lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. Preparation and characterization of gastroretentive floating. Pdf microemulsion route to the synthesis of nanoparticles. Evolution of controlled drug delivery systems since 1950. The only real disadvantage of microemulsions is the relatively higher level of emulsifier required. Introduction the practice of herbal medicine has existed since prehistoric times as the primary form of medicine.
The work in this thesis consists of three aspects, 1 synthesis of barium hexaferrite and strontium hexaferrite powders and formulation of barium hexaferrite and strontium hexaferrite thick film pastes for thick film delineation. It is a pleasure to convey my gratitude to them all through this acknowledgment. Novel formulations of antioxidant and antiinflammatory. This thesis concludes by researching an application of nanoemulsions. I am incredibly fortunate to have professor acosta as. Microemulsions are clear, stable, isotropic liquid mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. This thesis arose in part out of years of research that has been done since i came to the harth group at vanderbilt. Pdf microemulsion systems containing bioactive natural oils. Schematic outline of the human digestive tract with selfnanoemulsifying drug delivery system. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. Declaration i, gunjan tiwari, hereby declare that this project report entitled preparation and characterization of ketoconazole encapsulated liposome and ethosome. Novel formulations of antioxidant and antiinflammatory drugs. Microemulsion definition is an emulsion in which the dispersed phase is in the form of very small droplets usually produced and maintained with the aid of surfactants and having diameters of from 50 to 500 angstroms.
Microemulsions microemulsions are thermodynamically stable, optically transparent, isotropic dispersions of aqueous and hydrocarbon liquids stabilized by an interfacial film of surfactant molecules microemulsions show diverse structural organizations due to wide range of surfactant concentrations, wateroil ratios, temperature etc. Dissertation submitted to the faculty of the graduate school of vanderbilt university in partial fulfillment of the requirements for the degree of. The floating microspheres were collected by decantation, while the non floating microspheres were discarded along with any polymer precipitates. During that time, i have worked with a great number of people whose contribution, in assorted ways, to the research and the making of this thesis deserve special mention. Preparation of nano and microemulsions using phase. Sep 09, 2009 salicylic acid sa is a keratolytic agent used in topical products with antimicrobial actions. Microemulsion method for synthesis of magnetic oxide. Lecithinlinker microemulsionbased gels for drug delivery xiao yue xuan master of applied science department of chemical engineering and applied chemistry university of toronto.
Microemulsion formulations have distinct advantages over macroemulsion systems when delivered parenterally because of the fine particle microemulsion is cleared more slowly than the coarse particle emulsion and, therefore, have a longer residence time in the body. This tutorial was created to help you learn how to convert your own thesis or dissertation into a pdf file using adobe acrobat standard or professional. A mechanism for the recovery and purification of selected molecules in different environments a thesis submitted for the qualification of phd by micheal whelehan bsc hons april 2010 under the supervision of. Preparation of nano and microemulsions using phase inversion and emulsion titration methods. A comparative study submitted to national institute of technology, rourkela for the partial fulfillment of the master degree in life science is a faithful record of bonafide and. Oil and water are immiscible and they separate into two phases when mixed, each saturated with traces of the other component capek, 1999. Microemulsion definition of microemulsion by merriamwebster.
Salicylic acid sa is a keratolytic agent used in topical products with antimicrobial actions. There are several certain requirements, which must be. A nanoemulsion formulation of dacarbazine reduces tumour size in a xenograft mouse epidermoid carcinoma model compared to a dacarbazine suspension. Micelles, microemulsions, liquid crystals, and the structure. Regarding surface, im wondering if a rationale couldnt be built around 2 things. Enzymes in low water content and have, increased solubility in nonpolar reactants. Isbn 9789535102472, pdf isbn 9789535149712, published 20120316. Since 1995, mit has been developing the technology for a micro gas turbine engine capable of producing tens of watts of power in a package less than one cubic centimeter in volume. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Physicalchemical characterisation, acta pharmaceutica hungarica 78 2008 1121 if.
Nanoemulsions as vehicle for topical administration of glycyrrhetic acid characterization and in vitro and in vivo evaluation. Preparation of nano and microemulsions using phase inversion. In this space age where the technology has very much advanced. Salicylic acid sa is a white fluffy crystalline powder, slightly soluble in water 1 in 460 ml. Marsion laboratory of integrated bioprocessing school of biotechnology dublin city university ii. Nadeem irfan bukhari 4 march 01, 2004 to november 04, 2008 lecturer in pharmaceutics, school of pharmacy, international medical university. Dynamical system modeling of a micro gas turbine engine. The microspheres were dried in an oven at 50 0c for 2h, weighed and then stored in a desiccator at room temperature till further use. Micro and nanosystems provides a very fast and best forum for experimental and theoretical studies of fundamental and interdisciplinary research on micro and nanoscales. Theses with an embargo are shown in apollo with a padlock icon over the pdf file are not open access but can be requested. Abstracts and conference lectures related to the subject of this thesis op oral presentation. In recent years, the development and use of biofuels have received considerable. Science and technology on micro and nanoscales have been attracting great attention globally.
The demo engine developed for this research has low and diabtic component performance and severe heat transfer from the turbine side to the compressor side. Find student theses the university of baths research portal. Synthesis and characterization of superparamagnetic iron. Access to cambridge theses scholarly communication. Synthesis, characterization and further works on functionalization for biomedical purposes are main topics of discussion. In some respects, microemulsions can be considered as smallscale. Novel formulations of antioxidant and antiinflammatory drugs to ameliorate ischemic damage measured in vitro philip kin liang master of science graduate department of physiology university of toronto 2009 abstract the two of major pathways that cause ischemic damage are oxidative stress and inflammation.
Sz ucs maria, budai szabolcs, er os istvan, gelemulsion systems i. A thesis presented by jose daniel colmenares araque submitted to the graduate school of the university of massachusetts amherst in partial fulfillment of the requirements for the degree of masters. Microemulsion systems containing bioactive natural oils. Different concentrations of sa were incorporated in an me base composed of isopropyl myristate, water, and tween 80. The rapidly increasing number of applications for microemulsions has kept this relatively old topic still at the top point of research themes. Microemulsions are transparent, thermodynamically stable, isotropic mixtures of oil and water stabilized by an interfacial film of surfactant molecules frequently in combination with a cosurfactant, which used to stabilize the systems. Microtypographic extensions to the tex typesetting system. Preparation and evaluation of microemulsion systems. Preparation and characterization of ketoconazole encapsulated. Stability, acta pharmaceutica hungarica 78 2008 2330 if. A thesis submitted for the qualification of phd by micheal whelehan bsc hons april 2010 under the supervision of prof. Biphasic media also used for these type of reaction.
Guidance on the submission of theses for research degree programmes. This book provides an assessment of some issues influencing the characteristics and performance of the microemulsions, as well as their main types of applications. Microemulsions are considered to be infinitely stable, thereby providing improved stability over traditional macroemulsion systems. Jan 27, 2015 regarding surface, im wondering if a rationale couldnt be built around 2 things. Oems have proved mostly bad at designing andor selling premium product, which on top of lowering marginsprofits, also hands the premium market over to apple, and damages the image of the whole windows ecosystem. Therefore, the present study was conceived to develop bawo 4 nanoparticles in a waterinoil wo microemulsion system composed of 1,4dioxane and water. These systems are of interest to the food scientist due to their significant potential. Preparation of nicotinamide microemulsions and formulation. Upon mild agitation followed by dilution in aqueous media, such as gastrointestinal gi fluids, the systems can form fine oil in water ow microemulsions which usually have. Rearrange individual pages or entire files in the desired order.
It was shown that up to 30% oil can be incorporated within the polysaccharide particles although the viscosity reduces with increasing oil inclusion. The aqueous phase may contain salts andor other ingredients, and the oil may actually be a complex mixture of different hydrocarbons and. Microemulsions an introduction to properties and applications. In this thesis superparamagnetic iron oxide nanoparticles spions coated with silica will be observed. Finally, i send my unconditional thank you to my family mom, dad, and brother for their support. Oral microemulsions of pac were developed that increased both the permeability and auc of pac as compared to control14. Pdf microemulsion systems containing bioactive natural. Microemulsion method for synthesis of magnetic oxide nanoparticles by a. Biomedical applications require highest quality nanomaterials.
Many people have helped me to improve the thesis by proofreading and giving comments. A thesis presented by jose daniel colmenares araque submitted to the graduate school of the university of massachusetts amherst in partial fulfillment of the requirements for the degree of masters of science september 2015. Many enzymatic and biocatalytic reactions are conducted in pure organic or aqua organic media. Selfnanoemulsifying drug delivery systems snedds for the. Submit your thesis york graduate research school, the university. This is to certify that the thesis entitled preparation and characterization of ketoconazole encapsulated liposome and ethosome. If you have to send your thesis as multiple files please label each file clearly to include the volume or appendix number in the file name. The use of water poor media is relatively advantageous. Thesis formulation and investigation of gelemulsions. It is used as keratolytic agent in topical products, and it has antimicrobial and fungicidal actions 7 9. How to add a research thesis orca cardiff university. Both ow and wo microemulsion can be used for parenteral delivery. Find student theses the university of northamptons research. In chapter 1 a short introduction about the background, various aspects.
Mechanisms of selfnanoemulsifying drug delivery systems to improve bioavailability. Make sure the thesis is in the correct format a single pdf file is preferred. Preparation and characterization of gastroretentive. Thesis title preparation of nicotinamide microemulsions and formulation development for cosmetic application author miss nattiya suksawad major program master of sciences program in cosmetic sciences international program academic year 2010 abstract this thesis aimed to investigate the phase behavior of systems. Characterization and combustion performance of corn oilbased biofuel blends. Lecithinlinker microemulsion based gels for drug delivery xiao yue xuan master of applied science department of chemical engineering and applied chemistry university of toronto 2011 abstract microemulsions have gained interest from the pharmaceutical industry due to their ability to co.